Another season of hastily arranged friendlies and wartime regional leagues. Cyril Spiers uses 41 different players during the season, utilising many local amateurs, some of who are to become well known names in later years, such as Billy Baker, Beriah Moore and Reg Parker. Billy James starts to make something of a name for himself as well. Most matches are not particularly well attended, possibly because standards are none too high and times are hard.
The City team that beat Reading 4-1 on 15 March 1941.| Date | Opponents | Competition | V. | Res. | Goalscorers | Att. | |
| August 31 | Reading | Wartime South League | A | 0-2 | L | 2,861 | |
| September 7 | Reading | Wartime South League | H | 2-2 | D | James, Moore | 3,000 |
| September 14 | Birmingham City | Wartime South League | H | 5-2 | W | Moore 3, James, Parker | 2,175 |
| September 21 | Birmingham City | Wartime South League | A | 2-3 | L | Pugh, James | 3,500 |
| September 28 | Bristol City | Wartime South League | H | 2-2 | D | James, Wrigglesworth | 3,500 |
| October 5 | Bristol City | Wartime South League | A | 0-1 | L | 1,546 | |
| October 12 | Coventry City | Wartime South League | A | 2-5 | L | Parker 2 | 2,700 |
| October 19 | Coventry City | Wartime South League | H | 2-2 | D | James, Hollyman | 3,000 |
| October 26 | Swansea Town | Wartime South League | H | 8-0 | W | James 3, Moore 3, Parker 2 | 4,000 |
| November 2 | Army XI | Friendly | H | 18-1 | W | James 7, Scott 5, Parker 2, Moore 2, Allen, Pugh | 1,000 |
| November 9 | Southampton | Wartime South League | A | 3-1 | W | Moore 2, Parker | 2,000 |
| November 16 | Southampton | Wartime South League | H | 1-1 | D | Moore | 1,500 |
| November 23 | Bristol City | Wartime South League | A | 1-4 | L | James | 2,500 |
| November 30 | Bristol City | Wartime South League | H | 5-1 | W | James 2, Moore, Scott, Wood | 2,000 |
| December 7 | Stoke City | Wartime South League | A | 1-5 | L | Steggles | 1,800 |
| December 14 | Stoke City | Wartime South League | H | 4-0 | W | Morris, James 3 | 1,000 |
| December 21 | Bournemouth & B.A. | Wartime South League | A | 5-2 | W | Moore 2, James, Baker, Parker | 800 |
| December 25 | Swansea Town | Wartime South League | A | 2-1 | W | Moore, James | 3,000 |
| December 26 | Regional XI | Friendly | A | 1-3 | L | Jones T. | 1,200 |
| December 28 | Bournemouth & B.A. | Wartime South League | H | 1-3 | L | Jones T. | 4,000 |
| January 11 | Bristol City | Wartime South League | H | 5-2 | W | Moore 2, James 2, Joy | 2,000 |
| January 25 | Swansea Town | Wartime South League | A | 3-2 | W | Moore 2, James | 1,500 |
| February 8 | Bristol City | Wartime South League | A | 7-4 | W | Moore 4, Parker, Pugh, Williams | 1,500 |
| February 15 | Swansea Town | League Cup (1-1) | H | 3-2 | W | Moore, Parker, James | 4,000 |
| Swansea Town | League Cup (1-2) | H | 6-2 | W | Moore 3, Parker 2, James | 4,000 | |
| March 8 | Reading | League Cup (2-1) | A | 1-0 | W | James | 5,000 |
| March 15 | Reading | League Cup (2-2) | H | 4-1 | W | James 2, Baker, Moore | 10,000 |
| March 22 | Tottenham Hotspur | League Cup (3) | A | 3-3 | D | Moore 2, Barnes | 5,000 |
| March 29 | Tottenham Hotspur | League Cup (3R) | H | 2-3 | L | James, Parker | 21,000 |
| April 5 | Bath City | Western Regional League | A | 1-2 | L | James | 1,500 |
| April 12 | Lovell's Ath. | Western Regional League | H | 3-2 | W | James 2, Parker | 2,500 |
| April 14 | Aberaman | Western Regional League | H | 2-2 | D | Moore, Parker | 750 |
| April 19 | Lovell's Ath. | Western Regional League | A | 1-2 | L | Moore | 2,000 |
| April 26 | Bath City | Western Regional League | H | 5-2 | W | James 3, Moore 2 | 1,700 |
| May 10 | Chelsea | Friendly | H | 1-2 | L | Tobin | 4,000 |
| May 17 | W.B.A. | Wartime South League | H | 4-4 | D | Parker 2, James 2 | 3,009 |
| May 24 | Portsmouth | Wartime South League | H | 4-1 | W | Walker (og), Moore 2, Parker | 2,723 |
| May 31 | Wolverhampton W. | Wartime South League | H | 5-1 | W | James 2, Moore, Jones T., Parker | 4,204 |
| June 3 | Lovell's Ath. | League Cup Final | H | 1-6 | L | Hollyman |